Correlation Engine 2.0
Clear Search sequence regions

  • behavior (1)
  • lithium (1)
  • rats (2)
  • saccharin (4)
  • sodium (1)
  • Sizes of these terms reflect their relevance to your search.

    The current study investigated whether internal pain-inducing agents can modulate palatability of a tastant in the same way as illness-inducing agents (e.g., lithium chloride). Similar to traditional conditioned taste aversion (CTA) experiments, during conditioning the rats were exposed to a saccharin solution followed by intraperitoneal injections of either gallamine (Experiment 1) or hypertonic sodium chloride (NaCl; Experiments 1 and 2). In addition to the total amount consumed, the time of each lick was recorded for lick pattern analysis. The results showed that both gallamine and hypertonic NaCl caused suppression in saccharin intake. Importantly, both lick cluster size and initial lick rate (the measures of taste palatability) were reduced as well. This pattern of results suggests that these pain-inducing agents reduce the hedonic value of the associated tastant and thus CTA is acquired. The current finding serves as evidence supporting the view that CTA is a broadly tuned mechanism that can be triggered by changes in internal body states following consummatory experience. Copyright © 2013 Elsevier Inc. All rights reserved.


    Jian-You Lin, Joe Arthurs, Steve Reilly. Reduced palatability in pain-induced conditioned taste aversions. Physiology & behavior. 2013 Jul 02;119:79-85

    Expand section icon Mesh Tags

    Expand section icon Substances

    PMID: 23769688

    View Full Text