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Exogeneous pathogen-associated molecular patterns and endogenous danger signals bind to pattern recognition receptors and activate innate immunity cells, leading to proinflammatory cytokine production and activation of acquired immue cells. These are important factors in the pathogenesis of autoimmune-mediated neuroimmunological disorders such as multiple sclerosis. Furthermore, recent advances in the study of innate immunity revealed that innate immunity is a major players in the pathogenesis of some neuroimmunological diseases such as Beh├žet's disease and herpes simplex virus encephalitis.

Citation

Sachiko Miyake. Innate immunity in neuroimmunological disorders]. Nihon rinsho. Japanese journal of clinical medicine. 2013 May;71(5):778-82

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PMID: 23777081

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