Associations of urinary metal concentrations and circulating testosterone in Chinese men.
Qiang Zeng, Bin Zhou, Wei Feng, Yi-Xin Wang, Ai-Lin Liu, Jing Yue, Yu-Feng Li, Wen-Qing Lu
Department of Occupational and Environmental Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; MOE (Ministry of Education) Key Laboratory of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China; State Key Laboratory of Environment Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, PR China.
Reproductive toxicology (Elmsford, N.Y.) 2013 Jun 17Toxicological studies have shown that metals directly or indirectly influence testosterone (T) production, but the data from humans is limited and inconsistent. The aim of this study is to examine the associations between urinary metal concentrations and circulating T in Chinese men. Urinary concentrations of 13 metals (arsenic, cadmium, cobalt, chromium, copper, iron, lead, manganese, molybdenum, mercury, nickel, selenium and zinc) and serum levels of T were analyzed in 118 men from an infertility clinic. Multivariable linear regression was used to assess the effect of metals exposure on T. Among the measured metals, the median urinary Zn (359.36μg/g creatinine) and Co (0.16μg/g creatinine) concentrations were the highest and the lowest, respectively. Significant dose-response relationships were found between decreased T and urinary Mn and Zn, even when considering multiple metals (both P for trend<0.05). Our results indicate that elevated Mn and Zn are inversely associated with T production. Copyright © 2013. Published by Elsevier Inc.
Citation
Qiang Zeng, Bin Zhou, Wei Feng, Yi-Xin Wang, Ai-Lin Liu, Jing Yue, Yu-Feng Li, Wen-Qing Lu. Associations of urinary metal concentrations and circulating testosterone in Chinese men. Reproductive toxicology (Elmsford, N.Y.). 2013 Jun 17
PMID: 23791927
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