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To study the effects of Geniposide on SNP(sodium nitroprusside)-induced apoptosis of chondrocyte in vitro and cell cycle. The chondrocyte of three-week-old SD rats were separated and cultivated. The second generation of chondrocyte cells were involved in experiment. Chondrocyte proliferation was measured by assay; flow cytometer were adopted to observe cell cycle and apoptosis rate; NO examination adopted nitrate reductase method. Geniposide could significantly decrease the percentage of SNP-induced chondrocytes in G0/G1 phase and increased percentage in S phase and G2/M phase. The apoptosis of chondrocyte and the concentration of NO in the culture supernatants was reduced significantly (r=0.917, P<0.01). Geniposide could impact SNP-induced apoptosis of chondrocyte by reducing the concentration of NO in the culture supernatants, promoting proliferation of chondrocytes, which is a probable and important mechanism of Geniposide preventing osteoarthritis.

Citation

Wan-Jun Chen, Tong-Zhu Bao, Ken Chen, Chang-Mou Zhu, Feng Wan, Yu-Lin Tan, Fei Yan. Effects of geniposide on SNP-induced apoptosis of chondrocyte and cell cycle]. Zhongguo gu shang = China journal of orthopaedics and traumatology. 2013 Mar;26(3):232-5

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PMID: 23795444

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