Application of biomarker CTX- II in osteoarthritis].

Xue-Zong Wang, Ning-Yang Gao, Ting Liu, Jun Shen, Song-Pu Wei, Yu-Xin Zheng, Yue-Long Cao, Hong-Sheng Zhan

Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Zhongguo gu shang = China journal of orthopaedics and traumatology 2013 Mar

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Effective biomarkers for clinical usage of osteoarthritis are still limited. It was confirmed that C-terminal crosslinking telopeptide of type I collagen (CTX- II) was a specific marker reflecting degradation of articular cartilage. Detection of CTX- II could promptly reflect level of cartilage injury and degradation ,diagnose OA,predict its progress,monitor effects of drug treatment, thus, reflect the condition of osteoarthritis patient indirectly. Application of CTX- II focused mainly on in the early stage of OA and need together to detect with other biomarkers,in order to more accurately reflection of the pathological changes of OA,but the specific clinical significance of CTX- II results still need to improve further.

Citation

Xue-Zong Wang, Ning-Yang Gao, Ting Liu, Jun Shen, Song-Pu Wei, Yu-Xin Zheng, Yue-Long Cao, Hong-Sheng Zhan. Application of biomarker CTX- II in osteoarthritis]. Zhongguo gu shang = China journal of orthopaedics and traumatology. 2013 Mar;26(3):260-3