The total synthesis of hypodematine.

Zhi-Yun Kang, Qing-Jian Zhang, Ruo-Yun Chen, Pei-Cheng Zhang, De-Quan Yu

a State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Peking Union Medical College and Chinese Academy of Medical Sciences , Beijing , 100050 , China.

Journal of Asian natural products research 2013 Aug

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Hypodematine, isolated from Hypodematium sinense Iwatsuki as an alkaloid with a new skeleton, was synthesized via nine reaction steps, in which the synthesis of 2-aryl-1-benzazocines via Beckmann rearrangement of 5H-benzocyclohepten-5-one oxime mesylate in dry toluene is discussed.

Citation

Zhi-Yun Kang, Qing-Jian Zhang, Ruo-Yun Chen, Pei-Cheng Zhang, De-Quan Yu. The total synthesis of hypodematine. Journal of Asian natural products research. 2013 Aug;15(8):840-8

PMID: 23795612

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