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Bioconversion of 19-deformyl-5-O-desosaminyl tylonolide to 19-deformyl-4'-deoxydesmycosin (TMC-016).
Research Laboratories, Toyo Jozo Co., Ltd., Shizuoka, Japan.
FEMS microbiology letters 1990 MaySizes of these terms reflect their relevance to your search.
Bioconversion of 19-deformyl-5-O-desosaminyl tylonolide (1) to 19-deformyl-4'-deoxydesmycosin (3) was performed by using a mycinamicin-producing Micromonospora species. Compound 1 at low concentrations was completely converted to compound 3, however, the conversion to compound 3 was suppressed at high concentrations and 19-deformyl-4'-deoxy-2", 3'-di-O-demethyl-desmycosin (2), an intermediate leading to compound 3 accumulated.
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T Fujiwara, S Takenaka. Bioconversion of 19-deformyl-5-O-desosaminyl tylonolide to 19-deformyl-4'-deoxydesmycosin (TMC-016). FEMS microbiology letters. 1990 May;57(1-2):101-3
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PMID: 2379808
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