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The complexity of the central nervous system calls for immunocytochemical procedures that allow target proteins to be localized with high precision and with opportunities for quantitation. Immunogold procedures stand out as particularly powerful in this regard. Although these procedures have found wide application in the neuroscience community, they present limitations and pitfalls that must be taken into account. At the same time, these procedures offer potentials that remain to be fully realized.


Mahmood Amiry-Moghaddam, Ole Petter Ottersen. Immunogold cytochemistry in neuroscience. Nature neuroscience. 2013 Jul;16(7):798-804

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PMID: 23799472

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