Caspase-3 expression in the tissues of experimental melanoma and its metastases during matrix metalloproteinase-9 inhibition].

Arkhiv patologii 2013 Jan-Feb

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The specific features of caspase-3 expression were studied in intact tissues and skin melanoma cells, by reducing the activity of matrix metalloproteinase-9 in vivo. Immunohistochemical examination revealed no significant changes in the expression of caspase-3 in the primary tumor cells. There were the greatest changes in the organs having metastastic melanomas (lung, liver, spleen) and significant differences between control and treatment groups (p<0.05), unlike cardiac and nephritic tissues where the similar distinctions were absent.

Citation

Caspase-3 expression in the tissues of experimental melanoma and its metastases during matrix metalloproteinase-9 inhibition]. Arkhiv patologii. 2013 Jan-Feb;75(1):19-23