The development of polymer immunoglobulin preparations to identify different serovars legionella pneumophilia in reaction of slide-agglutination].

G L Karbyshev, A N Narkevich, A P Kochetkova, L V Larionova, D I Simakova, E Iu Liukshina, L K Lysova, A N Terent'ev, A I Shelokhovich, O G Sokirkina

Klinicheskaia laboratornaia diagnostika 2013 Mar

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The article deals with the results of study targeted to develop polymer diagnostic preparation to identify epidemically significant serogroups Legionella pneumophilia. The preparation combines rate of record (1-5 min) of reaction of paragglutinining preparations with color visualization and demonstrative of reaction of volume agglomeration with polymer diagnosticums. The specially synthesized polymer microspheres were sensibilized with serums enriched with antibodies to lipopolysaccharide of corresponding serovar L. pneumophilia. The derived immunoglobulin diagnostic preparations detect agent of legionellesis in the reaction of slide-agglutination on glass during 1-5 min. The polymer diagnostic preparations provide positive reaction with culture of corresponding serovar and no reaction with other gomologic and geterologic agents of infectious diseases.

Citation

G L Karbyshev, A N Narkevich, A P Kochetkova, L V Larionova, D I Simakova, E Iu Liukshina, L K Lysova, A N Terent'ev, A I Shelokhovich, O G Sokirkina. The development of polymer immunoglobulin preparations to identify different serovars legionella pneumophilia in reaction of slide-agglutination]. Klinicheskaia laboratornaia diagnostika. 2013 Mar(3):47-9