Antibiotic drug minocycline: a potential therapeutic drug for methamphetamine-related disorders].

Kenji Hashimoto, Tamaki Ishima, Yuko Fujita, Lin Zhang

Division of Clinical Neuroscience, Chiba University Center for Forensic Mental Health, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan. hashimoto@faculty.chiba-u.jp

Nihon Arukōru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 2013 Apr

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Accumulating evidence suggests a role of inflammation in the pathophysiology of a number of neuropsychiatric diseases. The second generation antibiotic drug minocycline has potent neuroprotective and anti-inflammatory effects. We reported that minocycline could attenuate behavioral abnormalities and dopaminergic neurotoxicity in mice after administration of methamphetamine or 3,4-methylenedioxymethamphetamine (MDMA). Furthermore, we reported that minocycline was effective in the animal models of schizophrenia. Moreover, a double-blind, placebo-control, cross-over study showed that minocycline was effective in the rewarding effects in healthy human subjects. In this article, we would like to discuss minocycline as a potential therapeutic drug for methamphetamine-related disorders.

Citation

Kenji Hashimoto, Tamaki Ishima, Yuko Fujita, Lin Zhang. Antibiotic drug minocycline: a potential therapeutic drug for methamphetamine-related disorders]. Nihon Arukōru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence. 2013 Apr;48(2):118-25