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Doxycycline is a commonly prescribed antibiotic for the treatment of acne vulgaris. Often preferred to other tetracyclines due to a safer and milder side-effect profile, doxycycline is more frequently prescribed as a treatment of this common condition. To present a case report of a young patient who developed skin eruptions over the extremities; myalgias; fatigue; swelling involving the face, hands, and feet; headache; and mood changes after 2 years of using doxycycline. She promptly developed similar symptoms after a rechallenge with doxycycline 1 year later. This important finding will make practitioners more vigilant to the side effects of this medication despite its current safety profile and regardless of the time that a patient is using it.


Miriam Weinstein, Ronald Laxer, Joanna Debosz, Gino Somers. Doxycycline-induced cutaneous inflammation with systemic symptoms in a patient with acne vulgaris. Journal of cutaneous medicine and surgery. 2013 Jul-Aug;17(4):283-6

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PMID: 23815962

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