GC-MS investigation and acetylcholinesterase inhibitory activity of Galanthus rizehensis.

Buket Bozkurt Sarikaya, Nehir Unver Somer, Gulen Irem Kaya, Mustafa Ali Onur, Jaume Bastida, Strahil Berkov

Department of Pharmacognosy, Faculty of Pharmacy, Ege University, 35100 Bornova, Izmir, Turkey. buket.bozkurt@ege.edu.tr

Zeitschrift für Naturforschung. C, Journal of biosciences 2013 Mar-Apr

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GC-MS (gas chromatography-mass spectrometry) analyses of alkaloids in the aerial parts and bulbs of Galanthus rizehensis Stern (Amaryllidaceae), collected during two different vegetation periods, was performed. Twenty three alkaloids were identified in four different alkaloid extracts. Acetylcholinesterase (AChE) inhibitory activities of the alkaloid extracts were tested. Both the highest alkaloid diversity and the most potent inhibitory activity (IC50 12.94 microg/ml) were obtained in extracts from the bulbs of G. rizehensis collected during the fruiting period.

Citation

Buket Bozkurt Sarikaya, Nehir Unver Somer, Gulen Irem Kaya, Mustafa Ali Onur, Jaume Bastida, Strahil Berkov. GC-MS investigation and acetylcholinesterase inhibitory activity of Galanthus rizehensis. Zeitschrift für Naturforschung. C, Journal of biosciences. 2013 Mar-Apr;68(3-4):118-24