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The review is devoted to the chemical synthesis of oligoribonucleotides and the protecting groups used. In particular the existent methods of blocking 2'-OH function in nucleotide monomers for the RNA synthesis are discussed in detail.


A V Aralov, O G Chakhmakhchieva. Protection of 2'-hydroxyls in the chemical synthesis of oligoribonucleotides]. Bioorganicheskaia khimiia. 2013 Jan-Feb;39(1):3-25

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PMID: 23844504

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