Mycalol: A Natural Lipid with Promising Cytotoxic Properties against Human Anaplastic Thyroid Carcinoma Cells.
Adele Cutignano, Genoveffa Nuzzo, Daniela D'Angelo, Eleonora Borbone, Alfredo Fusco, Angelo Fontana
Istituto di Chimica Biomolecolare, Consiglio Nazionale delle Ricerche, Via Campi Flegrei 34, 80078, Pozzuoli, Napoli (Italy) http://www.icb.cnr.it.
Angewandte Chemie (International ed. in English) 2013 Aug 26From Antarctic waters: Human anaplastic thyroid carcinoma (ATC) cells which stably express antisense construct against nuclear high-mobility group A (HMGA) proteins were used in a novel phenotypic assay for screening marine natural extracts. The rational search led to the isolation and identification of a novel polyoxygenated linear lipid (1) that showed important and selective cytotoxicity against ATC-derived tumor cell lines. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Citation
Adele Cutignano, Genoveffa Nuzzo, Daniela D'Angelo, Eleonora Borbone, Alfredo Fusco, Angelo Fontana. Mycalol: A Natural Lipid with Promising Cytotoxic Properties against Human Anaplastic Thyroid Carcinoma Cells. Angewandte Chemie (International ed. in English). 2013 Aug 26;52(35):9256-60
PMID: 23857783
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