A case of advanced gastric cancer diagnosed as stage IV responding to combined modality therapy and surviving for a long duration].

Masanari Shimada, Nozomu Murakami, Yasuko Tanada, Naoki Endo, Shinichi Kadoya, Tetsuji Yamada, Hiroshi Kurumatani, Hisashi Doyama

Dept. of Surgery, Saiseikai Takaoka Hospital, Japan.

Gan to kagaku ryoho. Cancer & chemotherapy 2013 May

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A 47-year-old woman was diagnosed as advanced gastric cancer of cardia(poorly-differentiated adenocarcionoma), with multiple para-aortic lymph node and liver metastasis, in March, 2005. We attempted neo-adjuvant chemotherapy with docetaxel(DOC), cisplatin(CDDP), and S-1(DCS). After 3 courses of DCS, we confirmed that the para-aortic lymph nodes and liver metastasis became small. Then, we were able to perform total gastrectomy, splenectomy, and D2 lymph node dissection. Additionally, we performed an intraoperative radiofrequency ablation to the scar of the liver metastasis. Histopathologically, we identified lymph node metastases in #1 and #16b1 pre. S-1 and DOC were administered as adjuvant chemotherapy. At seven years since the operation, the patient has shown no signs of recurrence. Combined modality therapy for advanced gastric cancer diagnosed with stage IV can be an effective treatment, so we hope that it will be established as a standard therapy.

Citation

Masanari Shimada, Nozomu Murakami, Yasuko Tanada, Naoki Endo, Shinichi Kadoya, Tetsuji Yamada, Hiroshi Kurumatani, Hisashi Doyama. A case of advanced gastric cancer diagnosed as stage IV responding to combined modality therapy and surviving for a long duration]. Gan to kagaku ryoho. Cancer & chemotherapy. 2013 May;40(5):651-4