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There is a paucity of animal models of pythiosis, a life-threatening disease of humans and animals, the immunopathogenesis of which is poorly understood. A pythiosis model was developed by injecting Toll (Tl)-deficient Drosophila melanogaster flies with Pythium insidiosum zoospores. The infected Tl mutant flies had significantly lower survival rates (73.7%) than did control flies. This study reveals the important role of Tl pathway activation in fly immune response to pythiosis. © 2013 The Societies and Wiley Publishing Asia Pty Ltd.


Régis A Zanette, Janio M Santurio, Érico S Loreto, Sydney H Alves, Dimitrios P Kontoyiannis. Toll-deficient Drosophila is susceptible to Pythium insidiosum infection. Microbiology and immunology. 2013 Oct;57(10):732-5

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PMID: 23865688

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