Effect of agonists and antagonists of 5-HT2 receptors on rats with different choice of reinforcement value].

The influence of drugs, agonist (DOI) and antagonist (ketanserin) ofserotonin receptors 5-HT2 on the behavior of rats tested by the method of choice to the value of reinforcement was investigated. Depending on their preferences in food reinforcement rats were divided into self-control (choosing more valuable, delayed reinforcement) and impulsive (low value, immediate reinforcement) groops. An hour before the test animals were administrated i.p. DOI and ketanserin at a dose of 0.2 mg/kg. Evaluated parameters of rat behavior: number of clicks on a particular pedal, the latencies and the number of omitted responses. The administration of ketanserin resulted in a statistically significant decrease in the choice of low-value immediate reinforcement of impulsive rats, and did not statistically significant alter the behavior of self-control animals. After the administration of DOI no statistically significant changes in the choice of reinforcement were observed in the groups of impulsive and self-control rats. But the study of the effect this drug in tote without division into typological groups the decreasing in impulsivity was revealed. In some cases DOI reduced the number of missing responses, and ketanserin--reduced the latency of response.

Citation

M I Zaĭchenko, G Kh Merzhanova, G L Venetsian. Effect of agonists and antagonists of 5-HT2 receptors on rats with different choice of reinforcement value]. Zhurnal vyssheĭ nervnoĭ deiatelnosti imeni I P Pavlova. 2013 Mar-Apr;63(2):246-55

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PMID: 23866611

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