Correlation Engine 2.0
Clear Search sequence regions

Sizes of these terms reflect their relevance to your search.

Proinflammatory caspases play important roles in innate immunity. Much attention has focused on caspase-1, which acts to eliminate pathogens by obliterating their replicative niches as well as alerting the host to their presence. Now, emerging data have shed light on the lesser-studied proinflammatory caspase-11 in the combat between host and pathogens. Using the new tools available, researchers are further elucidating the mechanisms by which caspase-11 contributes to host defense. Here, we review the emerging understanding of caspase-11 functions and the mechanisms of activation and discuss the implications for human disease. Copyright © 2013 Elsevier Inc. All rights reserved.


Tessie M Ng, Denise M Monack. Revisiting caspase-11 function in host defense. Cell host & microbe. 2013 Jul 17;14(1):9-14

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 23870309

View Full Text