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Proinflammatory caspases play important roles in innate immunity. Much attention has focused on caspase-1, which acts to eliminate pathogens by obliterating their replicative niches as well as alerting the host to their presence. Now, emerging data have shed light on the lesser-studied proinflammatory caspase-11 in the combat between host and pathogens. Using the new tools available, researchers are further elucidating the mechanisms by which caspase-11 contributes to host defense. Here, we review the emerging understanding of caspase-11 functions and the mechanisms of activation and discuss the implications for human disease. Copyright © 2013 Elsevier Inc. All rights reserved.

Citation

Tessie M Ng, Denise M Monack. Revisiting caspase-11 function in host defense. Cell host & microbe. 2013 Jul 17;14(1):9-14


PMID: 23870309

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