New antifungal antibiotics, pradimicins D and E. Glycine analogs of pradimicins A and C.

Y Sawada, M Nishio, H Yamamoto, M Hatori, T Miyaki, M Konishi, T Oki

Bristol-Myers Research Institute, Ltd., Tokyo Research Center, Japan.

The Journal of antibiotics 1990 Jul

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New antifungal antibiotics pradimicins D and E were isolated from the culture filtrates of Actinomadura hibisca P157-2 (ATCC 53557) and its mutant A2660 (ATCC 53762). The structure of pradimicin D is N-[[(5S,6S)-5-O-[4,6-dideoxy-4-(methylamino)-3-O-(beta-D- xylopyranosyl)-beta-D-galactopyranosyl]-5,6,8,13-tetrahydro-1,6,9,14- tetrahydroxy-11-methoxy-3-methyl-8,13-dioxobenzo[a]naphthacen++ +-2-yl] carbonyl]glycine, based on spectral analyses compared to pradimicin A. Pradimicin E is the des-N-methyl analog of pradimicin D. Pradimicins D and E were equal in activity to pradimicin A in vitro against a variety of fungi and in vivo against Candida albicans A9540 in mice.

Citation

Y Sawada, M Nishio, H Yamamoto, M Hatori, T Miyaki, M Konishi, T Oki. New antifungal antibiotics, pradimicins D and E. Glycine analogs of pradimicins A and C. The Journal of antibiotics. 1990 Jul;43(7):771-7