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From micrograms to grams: scale-up synthesis of eribulin mesylate.
Melvin J Yu, Wanjun Zheng, Boris M Seletsky
Eisai Inc., Andover, MA, USA. Melvin_Yu@eisai.com
Natural product reports 2013 SepSizes of these terms reflect their relevance to your search.
The synthesis of eribulin mesylate from microgram to multi-gram scale is described in this Highlight. Key coupling reactions include formation of the C30a to C1 carbon-carbon bond and macrocyclic ring closure through an intramolecular Nozaki-Hiyama-Kishi reaction.
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Melvin J Yu, Wanjun Zheng, Boris M Seletsky. From micrograms to grams: scale-up synthesis of eribulin mesylate. Natural product reports. 2013 Sep;30(9):1158-64
PMID: 23896896
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