Novel electrospun nanotholits/PHB scaffolds for bone tissue regeneration.

Lauro Xavier Filho, Gabriel Molina Olyveira, Pierre Basmaji, Ligia Maria Manzine Costa

Department of Nanoscience and Advanced Materials-UFABC, Rua Santa Adélia, 166, Santo André-SP 09291-210, Brazil.

Journal of nanoscience and nanotechnology 2013 Jul

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Nanotholits is an osteoinductor or be, stimulates the bone regeneration, enabling bigger migration of the cells for formation of the bone tissue regeneration mainly because nanotholits are rich in minerals considered essential to the bone mineralization process on a protein matrix (otolin) as hydroxiapatite. In order to improve its biodegrability and bioresorption in new platforms for tissue engineering, it was electrospun PHB/nanotholits from aqueous solutions of this polymer at concentrations of nanotholits 1% (w/v) and compared morphological and thermal properties with PHB/nanotholits casting films. Electrospun PHB/nanotholits mats presents more symmetric nanopore structure than casting films mats observed by SEM images mainly because the orientation of pores along the longitudinal direction of the electrospun fibers. Nanotholits influences in PHB electrospun/casting was analyzed using transmission infrared spectroscopy (FTIR). TGA showed similar thermal properties but DSC showed distinct thermal properties and crystallinity process of the developed bionanocomposite mainly because of different processing.

Citation

Lauro Xavier Filho, Gabriel Molina Olyveira, Pierre Basmaji, Ligia Maria Manzine Costa. Novel electrospun nanotholits/PHB scaffolds for bone tissue regeneration. Journal of nanoscience and nanotechnology. 2013 Jul;13(7):4715-9