Jing Bao, Bo Yang, Yuyu Sun, Youli Zu, Ying Deng
Biomedical Engineering Program, University of South Dakota, 4800 North Career Avenue, Sioux Falls, South Dakota 57107, USA.
Journal of biomedical nanotechnology 2013 JulIn this study, a berberine-loaded electrospun poly-(epsilon-caprolactone) nanofibrous membrane (B-NFM) was formulated. The B-NFM was composed of uniform nanofibers with the average diameter of 190 +/- 53 nm. Whole blood assay revealed that the B-NFM had higher absorption capacity than gauze wound dressing (GWD) and non-drug-loaded nanofibrous membrane (NFM). Hemostatic studies showed that the B-NFM was more efficient at promoting blood clotting than GWD and NFM. B-NFM was also demonstrated to possess broad-spectrum antimicrobial activity. Biocompatibility studies indicated that B-NFM had good compatibility with skin fibroblast cells. These results suggested that the B-NFM can promote in vitro hemostasis to minimize wound bleeding, absorb biofluid to provide a favorable environment, inhibit on-site microbial agents to prevent wound infection, and support skin cell growth to facilitate wound healing. These data highly suggest a potential clinical use of B-NFM as wound dressing material.
Jing Bao, Bo Yang, Yuyu Sun, Youli Zu, Ying Deng. A berberine-loaded electrospun poly-(epsilon-caprolactone) nanofibrous membrane with hemostatic potential and antimicrobial property for wound dressing. Journal of biomedical nanotechnology. 2013 Jul;9(7):1173-80
PMID: 23909131
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