The use of salivary protein secretions as an in vivo model to study Mantel cell lymphoma progression and treatment.

Charles F Streckfus, Jorge Romaguera, Cynthia Guajardo-Streckfus

Dental Branch, Department of Diagnostic and Biomedical Sciences, University of Texas Health Science Center (UTHSC), Houston, Texas 77054, USA. charles.streckfus@uth.tmc.edu

Cancer investigation 2013 Aug

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The objective of this study was to compare the salivary protein profiles from an individual diagnosed with MCL before, during, and after chemotherapy. Saliva specimens acquire prior, during, and after chemotherapy. Specimens were analyzed using a LC-MS/MS mass spectrometer. The results of the study suggest salivary protein alterations secondary to MCL and that a number of the proteins were changed as a result of chemotherapeutic intervention suggesting that the treatment, from a proteomic perspective, was efficacious. The study suggests that salivary secretions may be used as in vivo model for studying MCL progression and treatment efficacy.

Citation

Charles F Streckfus, Jorge Romaguera, Cynthia Guajardo-Streckfus. The use of salivary protein secretions as an in vivo model to study Mantel cell lymphoma progression and treatment. Cancer investigation. 2013 Aug;31(7):494-9