Identification of origins of marker chromosomes using fluorescence in situ hybridization].

To assess the value of fluorescence in situ hybridization (FISH) and bacterial artificial chromosome FISH (BAC-FISH) for the diagnosis for patients with marker chromosomes. Sixteen patients with marker chromosomes were analyzed with technologies including GTG-banding, Q-banding, multiplex FISH and BAC-FISH. The marker chromosomes in the 16 patients were verified as der(Y) (2 cases), psu dic(Y) (1 case), psu dic(15) (1 case), dic(15) (1 case), del(Y) (1 case), r(X) (5 cases), i(14 or 22) (2 cases), i(18) (1 case). FISH and BAC-FISH can both verify the origin of marker chromosomes and provide accurate information for the diagnosis and treatment of patients.

Citation

Qiong Wu, Yulin Zhou, Hui Kong, Huan Zeng, Huinan Wu, Yanyan Sheng, Chaoyi Yang, Yunsheng Ge, Meijiao Cai, Tingting Huang, Jiayan Chen, Xiaolu Chen, Dongxing Zhou, Xingli Huang. Identification of origins of marker chromosomes using fluorescence in situ hybridization]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. 2013 Aug;30(4):415-9

PMID: 23926007

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