Increase in stearidonic acid by increasing the supply of histidine to oleaginous Saccharomyces cerevisiae.

Kazuyoshi Kimura, Yasushi Kamisaka, Hiroshi Uemura, Masakazu Yamaoka

Journal of bioscience and bioengineering 2014 Jan

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Increasing concentration of histidine significantly increased stearidonic acid production and cell growth in oleaginous Saccharomyces cerevisiae that has been genetically modified by Δsnf2 disruption, DGA1 and Δ6 desaturase gene overexpression, and LEU2 expression. High concentration of histidine in wild-type transformant and HIS3 expression in Δsnf2 transformant also increased stearidonic acid. Copyright © 2013 The Society for Biotechnology, Japan. Published by Elsevier B.V. All rights reserved.

Citation

Kazuyoshi Kimura, Yasushi Kamisaka, Hiroshi Uemura, Masakazu Yamaoka. Increase in stearidonic acid by increasing the supply of histidine to oleaginous Saccharomyces cerevisiae. Journal of bioscience and bioengineering. 2014 Jan;117(1):53-6