Counter-regulatory effects of phosphatidic acid on protein kinase C activity in the presence of calcium and diolein.

R M Epand, A R Stafford

Department of Biochemistry, McMaster University, Health Sciences Centre, Hamilton, Ontario, Canada.

Biochemical and biophysical research communications 1990 Aug 31

filter terms:

Phosphatidic acid can replace phosphatidylserine in the activation of protein kinase C. However, in the presence of diolein, the addition of Ca2+ results in the inhibition of the enzyme. This phenomenon could lead to a negative feedback regulation of protein kinase C activity as a result of stimulation of the cycling of phosphatidylinositol.

Citation

R M Epand, A R Stafford. Counter-regulatory effects of phosphatidic acid on protein kinase C activity in the presence of calcium and diolein. Biochemical and biophysical research communications. 1990 Aug 31;171(1):487-90