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Single-molecule photon-fueled DNA nanoscissors for DNA cleavage based on the regulation of substrate binding affinity by azobenzene.

Yuan Zou, Jie Chen, Zhi Zhu, Lianyu Lu, Yishun Huang, Yanling Song, Huimin Zhang, Huaizhi Kang, Chaoyong James Yang

The Key Laboratory of Analytical Science, Key Laboratory for Chemical Biology of Fujian Province, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China. cyyang@xmu.edu.cn.

Chemical communications (Cambridge, England) 2013 Aug 29


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  • azobenzene (1)
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  • dna cleavage (2)
  • regulation of binding (2)
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    A pair of single-molecule photo-responsive DNA nanoscissors for DNA cleavage based on the regulation of substrate binding affinity was designed and fabricated. Compared with other DNA nanomachines, our DNA nanoscissors have the advantages of a clean switching mechanism, as well as robust and highly reversible operation.

    Citation

    Yuan Zou, Jie Chen, Zhi Zhu, Lianyu Lu, Yishun Huang, Yanling Song, Huimin Zhang, Huaizhi Kang, Chaoyong James Yang. Single-molecule photon-fueled DNA nanoscissors for DNA cleavage based on the regulation of substrate binding affinity by azobenzene. Chemical communications (Cambridge, England). 2013 Aug 29;49(77):8716-8


    PMID: 23958857

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