Effect of anthrax immune globulin on response to BioThrax (anthrax vaccine adsorbed) in New Zealand white rabbits.

Nina V Malkevich, Subhendu Basu, Thomas L Rudge, Kristin H Clement, Ajoy C Chakrabarti, Ronald T Aimes, Gary S Nabors, Mario H Skiadopoulos, Boris Ionin

Antimicrobial agents and chemotherapy 2013 Nov

filter terms:

Development of anthrax countermeasures that may be used concomitantly in a postexposure setting requires an understanding of the interaction between these products. Anthrax immune globulin intravenous (AIGIV) is a candidate immunotherapeutic that contains neutralizing antibodies against protective antigen (PA), a component of anthrax toxins. We evaluated the interaction between AIGIV and BioThrax (anthrax vaccine adsorbed) in rabbits. While pharmacokinetics of AIGIV were not altered by vaccination, the vaccine-induced immune response was abrogated in AIGIV-treated animals.

Citation

Nina V Malkevich, Subhendu Basu, Thomas L Rudge, Kristin H Clement, Ajoy C Chakrabarti, Ronald T Aimes, Gary S Nabors, Mario H Skiadopoulos, Boris Ionin. Effect of anthrax immune globulin on response to BioThrax (anthrax vaccine adsorbed) in New Zealand white rabbits. Antimicrobial agents and chemotherapy. 2013 Nov;57(11):5693-6