Synthesis and enzymatic evaluation of phosphoramidon and its β anomer: Anomerization of α-l-rhamnose triacetate upon phosphitylation.

Qi Sun, Qingkun Yang, Shanshan Gong, Quanlei Fu, Qiang Xiao

Bioorganic & medicinal chemistry 2013 Nov 1

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A novel and efficient strategy for the synthesis of phosphoramidon and its β anomer has been developed by manipulating the anomerization of α-l-rhamnose triacetate upon phosphitylation. The experimental results suggest that proton transfer, bond rotation, and N atom are the key factors for the anomerization. The determined Ki and Kd values establish that phosphoramidon prepared by this method possesses excellent biological activity, and indicate that the contacts of rhamnose moiety with the enzyme have limited contribution to the binding. Copyright © 2013 Elsevier Ltd. All rights reserved.

Citation

Qi Sun, Qingkun Yang, Shanshan Gong, Quanlei Fu, Qiang Xiao. Synthesis and enzymatic evaluation of phosphoramidon and its β anomer: Anomerization of α-l-rhamnose triacetate upon phosphitylation. Bioorganic & medicinal chemistry. 2013 Nov 1;21(21):6778-87