Neuroendocrine tumors of digestive system: morphologic spectrum and cell proliferation (Ki67 index)].

V V Delektorskaia, N E Kushliskiĭ

Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk 2013

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This review deals with the analysis of up-to-date concepts ofdiferent types of human neuroendocrine tumors of the digestive system. It summarizes the information on the specifics of recent histological classifications and criteria of morphological diagnosis accounting histological, ultrastructural and immunohistochemical parameters. Current issues of the nomenclature as well as various systems of grading and staging are discussed. In the light of these criteria the results of the own research clinical value of the determination of cell proliferation in primary and metastatic gastroenteropancreatic neuroendocrine neoplasms on the basis of evaluation of the Ki67 antigen expression are also presented.

Citation

V V Delektorskaia, N E Kushliskiĭ. Neuroendocrine tumors of digestive system: morphologic spectrum and cell proliferation (Ki67 index)]. Vestnik Rossiĭskoĭ akademii meditsinskikh nauk / Rossiĭskaia akademiia meditsinskikh nauk. 2013(5):28-37