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    Coffee and other sources of methylxanthines and risk of Type I vs Type II endometrial cancer (EC) have not been evaluated previously. Prospective cohort of 23,356 postmenopausal women with 471 Type I and 71 Type II EC cases. Type I EC was statistically significantly associated with caffeinated (relative risk (RR)=0.65 for 4+ cups per day vs ≤1 cup per month: 95% confidence interval (CI): 0.47-0.89) but not decaffeinated (RR=0.76; 95% CI: 0.50-1.15) coffee intake; there were no associations with tea, cola or chocolate, or for Type II EC. The inverse association with caffeinated coffee intake was specific to women with a body mass index 30+ kg m(-2) (RR=0.56; 95% CI: 0.36-0.89). Coffee may protect against Type I EC in obese postmenopausal women.


    S Uccella, A Mariani, A H Wang, R A Vierkant, W A Cliby, K Robien, K E Anderson, J R Cerhan. Intake of coffee, caffeine and other methylxanthines and risk of Type I vs Type II endometrial cancer. British journal of cancer. 2013 Oct 01;109(7):1908-13

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    PMID: 24022184

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