Patient outcome after complete surgery for retroperitoneal sarcoma.

Aggressive surgery has been suggested for improving local tumor control in patients with retroperitoneal sarcoma (RS). This study aimed at investigating local disease-free and overall survival after complete surgery, in patients with RS. Retrospective data of patients submitted to complete surgery for RS were extracted from a prospectively-maintained database. Forty-three out of 78 patients (55%) presented with primary RS. Infiltrated organs were resected in 42 patients (54%). Patients presenting with recurrent (hazard ratio (HR)=5.57, p=0.002) and high-grade (HR 3.47, p=0.041) tumors were at higher risk of local recurrence. Microscopically-involved tumor resection margins (HR=3.47, p=0.04) and recurrent tumor at presentation (HR=2.49, p=0.008) were independent predictors of poor survival. Patients presenting with primary RS had longer local disease-free survival and overall survival than those with recurrent tumor after complete surgery. Complete surgery remains the standard-of-care for patients with primary RS.

Citation

Carlo Riccardo Rossi, Andrea Varotto, Sandro Pasquali, Luca Giovanni Campana, Simone Mocellin, Antonio Sommariva, Maria Cristina Montesco, Marco Rastrelli, Antonella Vecchiato, Pierluigi Pilati, Donato Nitti. Patient outcome after complete surgery for retroperitoneal sarcoma. Anticancer research. 2013 Sep;33(9):4081-7

PMID: 24023353

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