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Females with acute myocardial infarction (AMI) have a higher risk of adverse outcomes because of receiving less evidence-based medical care. Our aim was to investigate the gender disparity in early death after ST-elevation myocardial infarction (STEMI) in the current era. A total of 1429 consecutive patients with STEMI in the Liaoning district were analyzed. We compared hospital care and cardiac event data by sex for in-patients with acute STEMI within 24 hours of symptom onset. In the emergency reperfusion group (n = 754), in-hospital mortality occurred in 4.2% of the males and 11.2% of the females (P = 0.001). In the non-emergency reperfusion group (n = 675), in-hospital mortality occurred in 13.0% of the males and 22.9% of the females (P = 0.001). Multivariate Logistic regression analysis revealed female sex as an independent risk factor of death for STEMI patients during hospitalization (OR = 1.691, P = 0.007). After controlling for patients who died within 24 hr after admission, female sex was no longer an independent risk factor (OR = 1.409, P = 0.259). Female sex was an independent risk factor for in-hospital mortality of STEMI patients, which is explained by an excess of very early deaths.


Bo Zhang, Wei Zhang, Rong-Chong Huang, Yan Zhang, Jun Liu, Zheng-Guo Zheng, Da-Ming Jiang, Yu-Jiao Sun, Li-Na Ren, Xu-Chen Zhou, Guo-Xian Qi. Gender disparity in early death after ST-elevation myocardial infarction. Chinese medical journal. 2013 Sep;126(18):3481-5

PMID: 24034094

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