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    Efforts for the identification of diagnostic autoantibodies for neuro-Behcet's disease (NBD) have failed. Screening of NBD patients' sera with protein macroarray identified mitochondrial carrier homolog 1 (Mtch1), an apoptosis-related protein, as a potential autoantigen. ELISA studies showed serum Mtch1 antibodies in 68 of 144 BD patients with or without neurological involvement and in 4 of 168 controls corresponding to a sensitivity of 47.2% and specificity of 97.6%. Mtch1 antibody positive NBD patients had more attacks, increased disability and lower serum nucleosome levels. Mtch1 antibody might be involved in pathogenic mechanisms of NBD rather than being a coincidental byproduct of autoinflammation. © 2013.


    Burçak Vural, Elçin Sehitoğlu, Filiz Cavuş, Nazlı Yalçınkaya, Hazal Haytural, Melike Küçükerden, Canan Ulusoy, Elif Uğurel, Selin Turan, Leyla Bulut, Recai Türkoğlu, Erkingül Shugaiv, Murat Kürtüncü, Sükrü Atakan, Ali O Güre, Ahmet Gül, Mefkure Eraksoy, Gülşen Akman-Demir, Erdem Tüzün. Mitochondrial carrier homolog 1 (Mtch1) antibodies in neuro-Behçet's disease. Journal of neuroimmunology. 2013 Oct 15;263(1-2):139-44

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    PMID: 24035008

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