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A 38-year-old man with Marfan syndrome underwent an aortic replacement with an artificial aortic valve at 27 years of age and an aortic graft at 31 years of age. In 2011, he was diagnosed as having chronic necrotizing pulmonary aspergillosis (CNPA). He developed a fever and an increased sputum volume and was admitted to the hospital in 2012. Contrast-enhanced CT showed an irregularly shaped nonenhanced structure in the aortic graft. He died on hospital day 31. From the autopsy findings, we speculated that an infiltration by the CNPA lesion into a pulmonary vein was followed by the hematogenous formation of a fungus ball in the aortic graft.


Hideaki Yamakawa, Noboru Takayanagi, Takashi Ishiguro, Yosuke Miyahara, Yoshihiko Shimizu, Yutaka Sugita. An autopsy case of pulmonary aspergillosis with fungus ball formation in an artificial aortic graft. Internal medicine (Tokyo, Japan). 2013;52(18):2117-9

PMID: 24042523

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