In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract.

Trigonella foenum-graecum is one of the widely used herbs in food and medicine. The seeds of the plants are investigated for antidiabetic potential; however, no efforts have been done to explore the potential of leaves to modify carbohydrate metabolizing enzymes viz. α-amylase and α-glucosidase. The present work was designed to investigate the inhibitory potential of ethyl acetate and water extract of T. foenum-graecum on enzymes α-amylase and α-glucosidase. Different concentrations of extracts were used to study inhibition of enzymatic activity of α-amylase and α-glucosidase. A dose dependent inhibitory effect on enzymes was observed. The current study, for the first time, revealed α-amylase and α-glucosidase inhibitory potential of T. foenum-graecum and the study could be helpful to isolate and characterize compounds responsible for it.

Citation

Aditya Ganeshpurkar, Varsha Diwedi, Yash Bhardwaj. In vitro α -amylase and α-glucosidase inhibitory potential of Trigonella foenum-graecum leaves extract. Ayu. 2013 Jan;34(1):109-12

PMID: 24049415

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