CD46: the 'multitasker' of complement proteins.

Hidekazu Yamamoto, Antonella Francesca Fara, Prokar Dasgupta, Claudia Kemper

The international journal of biochemistry & cell biology 2013 Dec

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Complement is undeniably quintessential for innate immunity by detecting and eliminating infectious microorganisms. Recent work, however, highlights an equally profound impact of complement on the induction and regulation of a wide range of immune cells. In particular, the complement regulator CD46 emerges as a key sensor of immune activation and a vital modulator of adaptive immunity. In this review, we summarize the current knowledge of CD46-mediated signalling events and their functional consequences on immune-competent cells with a specific focus on those in CD4(+) T cells. We will also discuss the promises and challenges that potential therapeutic modulation of CD46 may hold and pose. Copyright © 2013 Elsevier Ltd. All rights reserved.

Citation

Hidekazu Yamamoto, Antonella Francesca Fara, Prokar Dasgupta, Claudia Kemper. CD46: the 'multitasker' of complement proteins. The international journal of biochemistry & cell biology. 2013 Dec;45(12):2808-20