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Venturicidin C (1), a new 20-membered macrolide along with the known venturicidins A (2) and B (3) were isolated from the crude extract of the Appalachian bacterial strain Streptomyces sp. TS-2-2. Additionally, nine other known compounds namely nocardamine, dehydroxynocardamine, desmethylenylnocardamine, ferrioxamine E, adenosine, riboflavin, cyclo(D)-trans-4-OH-Pro-(D)-Phe, cyclo(D)-Pro-(D)-Phe and N-(2-phenylethyl)-acetamide were also isolated and identified. The structure of the new macrolide 1 was elucidated by the cumulative analyses of NMR spectroscopy and HR-MS data. Complete NMR assignments for the known venturicidins A (2) and B (3) are also provided, for the first time, in this report. Venturicidins A-C did not inhibit the proliferation of A549 lung cancer cell line but all displayed potent antifungal activity.


Khaled A Shaaban, Shanteri Singh, Sherif I Elshahawi, Xiachang Wang, Larissa V Ponomareva, Manjula Sunkara, Gregory C Copley, James C Hower, Andrew J Morris, Madan K Kharel, Jon S Thorson. Venturicidin C, a new 20-membered macrolide produced by Streptomyces sp. TS-2-2. The Journal of antibiotics. 2014 Mar;67(3):223-30

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PMID: 24252813

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