Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses.

Stig M R Jensen, Francis W Ruscetti, Alan Rein, Daniel C Bertolette, Carrie J Saucedo, Barry R O'Keefe, Kathryn S Jones

Journal of virology 2014 Feb

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The antiviral lectins griffithsin (GRFT), cyanovirin-N (CV-N), and scytovirin (SVN), which inhibit several enveloped viruses, including lentiviruses, were examined for their ability to inhibit entry mediated by Env proteins of delta- and gammaretroviruses. The glycoproteins from human T-cell leukemia virus type 1 (HTLV-1) were resistant to the antiviral effects of all three lectins. For gammaretroviruses, CV-N inhibited entry mediated by some but not all of the envelopes examined, whereas GRFT and SVN displayed only little or no effect.

Citation

Stig M R Jensen, Francis W Ruscetti, Alan Rein, Daniel C Bertolette, Carrie J Saucedo, Barry R O'Keefe, Kathryn S Jones. Differential inhibitory effects of cyanovirin-N, griffithsin, and scytovirin on entry mediated by envelopes of gammaretroviruses and deltaretroviruses. Journal of virology. 2014 Feb;88(4):2327-32