Synthesis of ximelagatran, melagatran, hydroxymelagatran, and ethylmelagatran in H-3 labeled form.

In support of a study designed to better understand the liver toxicity of ximelagatran, ximelagatran, and melagatran, hydroxymelagatran and ethylmelagatran were prepared in tritium labeled form. Incorporation of tritium was achieved by hydrogen isotope exchange using Crabtree's catalyst and later with N-heterocyclic containing Ir catalyst. The tritiated product was then converted into the four target compounds to afford them in high purity and specific activity. Copyright © 2013 John Wiley & Sons, Ltd.

Citation

Roger Simonsson, Gunnar Stenhagen, Cecilia Ericsson, Charles S Elmore. Synthesis of ximelagatran, melagatran, hydroxymelagatran, and ethylmelagatran in H-3 labeled form. Journal of labelled compounds & radiopharmaceuticals. 2013 May 30;56(6):334-7

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PMID: 24285415

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