Correlation Engine 2.0
Clear Search sequence regions

Adenovirus fibre proteins play an important role in determining viral tropism. The C-terminal domain of the fibre protein from snake adenovirus type 1, a member of the Atadenovirus genus, has been expressed, purified and crystallized. Crystals were obtained belonging to space groups P2(1)2(1)2(1) (two different forms), I2(1)3 and F23. The best of these diffracted synchrotron radiation to a resolution of 1.4 Å. As the protein lacks methionines or cysteines, site-directed mutagenesis was performed to change two leucine residues to methionines. Crystals of selenomethionine-derivatized crystals of the I2(1)3 form were also obtained and a multi-wavelength anomalous dispersion data set was collected.


Abhimanyu K Singh, Rosa Menéndez-Conejero, Carmen San Martín, Mark J van Raaij. Crystallization of the C-terminal domain of the fibre protein from snake adenovirus 1, an atadenovirus. Acta crystallographica. Section F, Structural biology and crystallization communications. 2013 Dec;69(Pt 12):1374-9

Expand section icon Mesh Tags

Expand section icon Substances

PMID: 24316834

View Full Text