Synthesis and photophysical property studies of the 2,6,8-triaryl-4-(phenylethynyl)quinazolines.

Malose Jack Mphahlele, Hugues Kadem Paumo, Ahmed M El-Nahas, Morad M El-Hendawy

Molecules (Basel, Switzerland) 2014 Jan 10

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The 2-aryl-6,8-dibromo-4-chloroquinazolines derived from the 2-aryl-6,8-dibromoquinazolin-4(3H)-ones were subjected to the Sonogashira cross-coupling with terminal acetylenes at room temperature to afford novel 2-aryl-6,8-dibromo-4-(alkynyl)quinazoline derivatives. Further transformation of the 2-aryl-6,8-dibromo-4-(phenylethynyl)quinazolines via Suzuki-Miyaura cross-coupling with arylboronic acids occurred without selectivity to afford the corresponding 2,6,8-triaryl-4-(phenylethynyl)quinazolines. The absorption and emission properties of these polysubstituted quinazolines were also determined.

Citation

Malose Jack Mphahlele, Hugues Kadem Paumo, Ahmed M El-Nahas, Morad M El-Hendawy. Synthesis and photophysical property studies of the 2,6,8-triaryl-4-(phenylethynyl)quinazolines. Molecules (Basel, Switzerland). 2014 Jan 10;19(1):795-818