Correlation Engine 2.0
Clear Search sequence regions


  • cell (2)
  • cell death (2)
  • CYB5A (5)
  • humans (1)
  • patients (2)
  • phenotypes (1)
  • prognosis (3)
  • protein human (1)
  • tnf receptor (2)
  • vitro (1)
  • Sizes of these terms reflect their relevance to your search.

    The highly invasive and chemoresistant phenotype of pancreatic cancer highlights the urgency to identify prognostic biomarkers and novel therapeutic targets. Recently, we observed a significant correlation between shorter survival and loss of the cytoband 18q22.3. Here we investigated genes encoded by this cytoband, and demonstrated the prognostic value of CYB5A in resected and metastatic patients. Furthermore, our in vitro and in vivo studies clarified CYB5A inhibitory activity of oncogenic phenotypes through autophagy induction. This raises the possibility that inhibition of CYB5A-deregulated downstream pathways, such as those involving TRAF6, may favor autophagy-mediated cancer cell death in selected subgroups of patients.

    Citation

    Elisa Giovannetti, Giuseppe Giaccone. CYB5A and autophagy-mediated cell death in pancreatic cancer. Autophagy. 2014 Apr;10(4):697-8

    Expand section icon Mesh Tags

    Expand section icon Substances


    PMID: 24448000

    View Full Text