PDP1 regulates energy metabolism through the IIS-TOR pathway in the red flour beetle, Tribolium castaneum.

Zhiqian Li, Jianhao Jiang, Yazhou Chen, Lang You, Yongping Huang, Anjiang Tan, Zhiqian Li, Jianhao Jiang, Baolong Niu, Zhiqi Meng

Archives of insect biochemistry and physiology 2014 Mar

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The PAR-domain protein 1 (PDP1) is essential for locomotor activity of insects. However, its functions in insect growth and development have not been studied extensively, which prompted our hypothesis that PDP1 acts in energy metabolism. Here we report identification of TcPDP1 in the red flour beetle, Tribolium castaneum, and its functional analysis by RNAi. Treating larvae with dsTcPDP1 induced pupae developmental arrestment, accompanied by accelerated fat body degradation. dsTcPDP1 treatments in adults resulted in reduced female fecundity. Disruption of TcPDP1 expression affected the transcription of genes involved in insulin signaling transduction and mechanistic target of rapamycin (mTOR) pathway. These results support our hypothesis that TcPDP1 acts in energy metabolism in T. castaneum. © 2014 Wiley Periodicals, Inc.

Citation

Zhiqian Li, Jianhao Jiang, Yazhou Chen, Lang You, Yongping Huang, Anjiang Tan, Zhiqian Li, Jianhao Jiang, Baolong Niu, Zhiqi Meng. PDP1 regulates energy metabolism through the IIS-TOR pathway in the red flour beetle, Tribolium castaneum. Archives of insect biochemistry and physiology. 2014 Mar;85(3):127-36