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2-Aminopyridines via reaction of pyridine N-oxides and activated isocyanides.
The Journal of organic chemistry 2014 Mar 07Sizes of these terms reflect their relevance to your search.
A practical and efficient method for the synthesis of substituted 2-aminopyridines from pyridine N-oxides is reported. Yields of purified, isolated products of up to 84% are observed for the one-pot, two-step process. The reaction involves an in situ deprotection of an isolable N-formylaminopyridine intermediate and facilitates the synthesis of 2-aminopyridines for which other methods fail.
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Mitchell Vamos, Nicholas D P Cosford. 2-Aminopyridines via reaction of pyridine N-oxides and activated isocyanides. The Journal of organic chemistry. 2014 Mar 07;79(5):2274-80
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PMID: 24490824
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