Synthesis of chiral α-diarylacetic esters by stereospecific 1,2-aryl migration promoted by in situ generated acetals from benzoins.

Raveendra Babu Kothapalli, Ramana Niddana, Rengarajan Balamurugan

Organic letters 2014 Mar 7

filter terms:

A simple protocol for the synthesis of α-diarylacetic esters from benzoins is described. In situ generated acetal assists rapid 1,2-aryl migration in a stereospecific manner, paving the way to make enantioenriched α-diarylacetic esters from easily accessible enantiopure benzoins.

Citation

Raveendra Babu Kothapalli, Ramana Niddana, Rengarajan Balamurugan. Synthesis of chiral α-diarylacetic esters by stereospecific 1,2-aryl migration promoted by in situ generated acetals from benzoins. Organic letters. 2014 Mar 7;16(5):1278-81