Molecular mechanisms of dormancy and drug tolerance in mycobacteria].

Instead of rapid multiplication, pathogenic mycobacteria, such as Mycobacterium tuberculosis are likely to have acquired slow but long life. Host immunity affords desirable non-competitive environment for M tuberculosis in human lungs, where this pathogen slowly grows or arrests growing, which avoids rapid loss of living places. Mycobacterial DNA-binding protein 1 (MDP1), a unique histone-like protein associating mycobacterial GC-rich DNA, has pivotal role in realizing such slow life and pathogenesis including drug tolerance to isoniazid.

Citation

Sohkichi Matsumoto. Molecular mechanisms of dormancy and drug tolerance in mycobacteria]. Nihon Hansenbyō Gakkai zasshi = Japanese journal of leprosy : official organ of the Japanese Leprosy Association. 2013 Dec;82(3):119-22

Mesh Tags

Substances

PMID: 24579459

search → result