C/EBP-α, involvement of a novel transcription factor in leptin-induced VCAM-1 production in mouse chondrocytes.

Xia Kang, Qing-Yun Xie, Jing-Song Zhou, Bo Zhang, Dong-Fa Liao, Hong-Hua Wu, Wei Zheng, Xian-Ming Pan, Yi Quan

FEBS letters 2014 Apr 2

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Leptin and vascular cell adhesion molecules-1 (VCAM-1) are two important mediators in obesity-related osteoarthritis, while the molecular mechanism linking leptin to VCAM-1 production is still obscure. Here we show that leptin upregulates VCAM-1 mRNA and protein levels in a time- and dose-dependent manner. Mechanistically, leptin induces VCAM-1 promoter activity by increasing the expression of C/EBP-α and facilitating its binding to a newly identified element in the VCAM-1 gene. Gain or loss of function studies reveal a regulatory role of C/EBP-α on VCAM-1 expression. Finally, elevated plasma leptin level correlates to increased C/EBP-α and VCAM-1 production in chondrocytes from obese mice. Copyright © 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Citation

Xia Kang, Qing-Yun Xie, Jing-Song Zhou, Bo Zhang, Dong-Fa Liao, Hong-Hua Wu, Wei Zheng, Xian-Ming Pan, Yi Quan. C/EBP-α, involvement of a novel transcription factor in leptin-induced VCAM-1 production in mouse chondrocytes. FEBS letters. 2014 Apr 2;588(7):1122-7