Palladium-catalyzed direct arylation of indoles with cyclohexanones.

Shanping Chen, Yunfeng Liao, Feng Zhao, Hongrui Qi, Saiwen Liu, Guo-Jun Deng

Organic letters 2014 Mar 21

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A novel palladium catalyzed approach to 3-arylindoles was developed from indoles and cyclohexanones. Various cyclohexanones acted as aryl sources via an alkylation and dehydrogenation sequence using molecular oxygen as the hydrogen acceptor. This method showed good regioselectivity and afforded 3-arylindoles as the sole products.

Citation

Shanping Chen, Yunfeng Liao, Feng Zhao, Hongrui Qi, Saiwen Liu, Guo-Jun Deng. Palladium-catalyzed direct arylation of indoles with cyclohexanones. Organic letters. 2014 Mar 21;16(6):1618-21